MT-II (Melanotan II)

Synthetic melanocortin receptor agonist often discussed in relation to tanning and sexual function, primarily in experimental and non-regulated contexts.

Educational only

This page is for general educational and informational purposes only. It is not medical advice and does not replace professional medical judgment. Always consult a qualified clinician before starting, stopping, or changing any medication or protocol.

Overview

MT-II (Melanotan II) is a synthetic peptide that activates melanocortin receptors and is often discussed in relation to tanning and sexual function in experimental or non-regulated markets.

Many uses described in informal materials are outside the scope of approved medicines, and product quality and regulatory oversight vary widely between regions and suppliers.

Mechanism of action

MT-II acts on melanocortin receptors, including those involved in skin pigmentation and certain central nervous system pathways. High-level effects may include:

  • Influencing melanin production in the skin
  • Interacting with appetite and sexual function pathways in the brain

The balance of these effects, and how they vary between individuals, remains an area of ongoing research and debate.

Indications and use context

In many jurisdictions, MT-II is not an approved drug for cosmetic tanning or sexual function and may be encountered primarily in research or informal markets.

Any consideration of MT-II should take into account regulatory status, potential risks, and the availability of better-characterized options in approved therapeutic areas.

Safety and side effects

High-level safety themes

Safety information for MT-II is drawn from limited clinical studies and many anecdotal reports, and should be interpreted cautiously.

Reported effects include flushing, nausea, darkening of moles or new pigmented lesions, and changes in libido. Long-term safety, including dermatologic and cardiovascular outcomes, is not well established.

Given these uncertainties, risk–benefit discussions are particularly important and should be guided by clinicians.

Pharmacology and dosing considerations

MT-II is a potent melanocortin agonist. Protocols described in user communities emphasize extreme caution due to the risk of nausea and side effects.

Common administration patterns

Route: Subcutaneous injection.

Protocol structure and dosage:
  • Assessment dose: Very low initial dose (e.g., 50–100 mcg) to gauge tolerance (nausea/flushing).
  • Loading phase: 250 mcg to 500 mcg daily until desired pigmentation is achieved.
  • Maintenance phase: 250–500 mcg once or twice weekly.

Warning: High doses can cause severe nausea, spontaneous erections, and darkening of moles. User reports strongly advise against exceeding 1 mg per dose.

Formulations and combinations

MT-II often appears in catalogs as a lyophilized powder for reconstitution and may be conceptually grouped with other melanocortin or cosmetic peptides.

Structural listings in this catalog do not endorse particular cosmetic or performance-related uses.

Research and evidence snapshot

Research on melanocortin agonists has examined effects on pigmentation, appetite, and sexual function. For MT-II specifically, much of the available information comes from small studies and practice reports rather than large, long-term trials.

High-level summaries should therefore be treated as orientation rather than as a basis for clinical decisions.

Frequently asked questions

Future FAQs may address high-level questions such as how melanocortin biology relates to tanning and libido, what regulators have said about cosmetic tanning products, and how clinicians weigh cosmetic versus medical risk. Answers will remain educational and non-prescriptive.

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