This page describes how to reason about TB-500 vial amounts, dilution, and abstract exposure. It is not dosing advice and does not replace professional guidance or product labelling.
Overview
Many TB-500 questions mirror those asked for other lyophilized peptides:
- How much peptide is in a vial?
- How much diluent is added?
- What concentration does that produce?
- What volume corresponds to a hypothetical abstract amount?
The arithmetic is linear and generalizable: the same framework used for BPC-157 dosing concepts applies here as well.
Vial amount and dilution
TB-500 catalog entries often specify total peptide mass per vial (for example, 5 mg or 10 mg). This is the starting point for all subsequent calculations.
The chosen diluent volume (for example, 2 mL vs 4 mL) directly sets the resulting concentration. Larger volumes dilute the solution; smaller volumes concentrate it.
Concentration and volume per unit
Once a vial is reconstituted, you can think in terms of:
- Concentration (e.g., mg/mL or µg/mL).
- Volume per abstract unit (e.g., the volume corresponding to 2 mg in a theoretical protocol).
For example, if 10 mg is dissolved in 4 mL, the concentration is 2.5 mg/mL. A hypothetical 2 mg abstraction would map to 0.8 mL of that solution.
Exposure and kinetic concepts
True exposure depends on more than vial math. Pharmacokinetic factors such as absorption, distribution, metabolism, and elimination all play roles, and detailed human data for TB-500 are limited.
Conceptually, half-life and dosing interval influence how concentrations build up or decline over time. Visual tools can help illustrate these ideas without pretending that a single model fits all individuals.
Tools for checking calculations
To reduce arithmetic errors, structured tools can be useful:
The Peptide Calculator helps map between vial amount, dilution volume, and volume per abstract unit.
The Half-Life Plotter allows you to visualize theoretical concentration-time curves.
The Syringe Simulator can make unit volumes more concrete.
Conceptual, not prescriptive
Because TB-500 is not broadly approved as a therapeutic, there is no single, regulator-defined dosing framework that covers indications, contraindications, and monitoring. This page therefore remains strictly conceptual.
For foundational information, see the main TB-500 overview page and the safety-focused guide.
Sport & Anti-Doping Warning
TB-500 (a thymosin beta-4 fragment) is classified as a prohibited peptide hormone/growth factor and has appeared in elite-sport doping investigations, including endurance running cases where it was used alongside EPO and other banned agents.
- >Overview of peptide hormones and growth factors on the WADA Prohibited List (S2)
- >Reporting on TB-500 and other experimental peptides in performance contexts
Use of TB-500 by athletes governed by anti-doping rules is generally treated as a serious violation, particularly when combined with other anabolic or blood-boosting drugs.