HCG (human chorionic gonadotropin)
Hormone with LH-like activity used in regulated reproductive and endocrine medicine, and often discussed more broadly in wellness and performance contexts.
This page is for general educational and informational purposes only. It is not medical advice and does not replace professional medical judgment. Always consult a qualified clinician before starting, stopping, or changing any medication or protocol.
Overview
HCG (human chorionic gonadotropin) is a hormone produced during pregnancy that has luteinizing hormone (LH)–like activity. Purified and recombinant forms of HCG are used in regulated reproductive and endocrine medicine.
Beyond those indications, HCG is sometimes referenced in weight-loss or performance discussions, often in ways that diverge from evidence-based practice and local regulations.
Mechanism of action
Therapeutic HCG binds to LH receptors in the gonads, leading to:
- Stimulation of sex-steroid production (e.g., estrogen and progesterone in the ovary)
- Support of ovulation or corpus luteum function in fertility protocols
- In certain endocrine contexts, support of testosterone production in males by acting on Leydig cells
These effects underpin both established reproductive uses and some of the off-label or experimental contexts in which HCG is discussed.
Indications and use context
In regulated medicine, HCG may be used:
- As part of assisted reproductive protocols to trigger ovulation or support luteal function
- In selected endocrine conditions to stimulate endogenous testosterone production in males under specialist care
Exact indications, combinations, and dosing strategies are defined by product labeling and specialist guidelines. Uses of HCG in weight-loss regimens or unsupervised hormone manipulation are controversial and often not aligned with regulatory or evidence-based standards.
Safety and side effects
Safety considerations for HCG are closely tied to its hormonal effects and how it is used within broader protocols.
Reported risks include ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy in fertility settings, as well as injection-site reactions, mood changes, and various hormone-related symptoms. In males, endocrine testing and careful monitoring are important when HCG is used for hypogonadal conditions.
Because effects depend strongly on context and co-therapies, safety assessment should always be individualized and clinician-led.
Pharmacology and dosing considerations
HCG mimics LH and is used to stimulate testicular or ovarian function. Protocols differ vastly between fertility, hypogonadism, and diet contexts.
Route: Subcutaneous injection or Intramuscular (IM).
Protocol structure and dosage:- Fertility (Trigger Shot): Single dose of 5,000 to 10,000 IU.
- Hypogonadism/PCT: 250 IU to 500 IU administered 2–3 times weekly.
- HCG Diet (Controversial): 125 IU to 250 IU daily (not evidence-based).
Note: HCG raises testosterone levels in men but suppresses natural LH/FSH production via negative feedback if used for long periods without breaks.
Formulations and combinations
HCG products appear as vials or prefilled syringes and may be used alongside other gonadotropins or hormone treatments in structured fertility protocols.
Catalog entries for HCG in this site list structural vial codes and specifications. They do not indicate which combinations or regimens, if any, are appropriate for individual patients.
Research and evidence snapshot
HCG has been studied extensively as part of assisted reproductive technologies and in selected endocrine conditions. Outcomes include ovulation and pregnancy rates, sex-steroid levels, and safety endpoints such as OHSS.
In contrast, evidence for HCG-based weight-loss approaches or other non-standard uses is limited and often does not support strong claims. Interpretation of HCG research therefore depends heavily on the clinical question being asked.
Frequently asked questions
Future FAQs may address how clinicians decide between different reproductive hormone protocols, why HCG has appeared in weight-loss narratives, and what regulators and guidelines say about off-label use. Answers will remain educational and non-prescriptive.
Sport & Anti-Doping Warning
Human chorionic gonadotropin (hCG) has been misused by male athletes as part of steroid cycles to stimulate endogenous testosterone and is specifically prohibited in male competitors.
- >Scientific discussion of hCG misuse and detection in athletes
- >Coverage of recent professional sport suspensions for hCG positives
In anti-doping rules, hCG is banned in males and often treated as a marker of attempted steroid cycle manipulation rather than a benign fertility drug.
Comments
Loading comments...
Get the Standard Protocols.
Join 12,000+ researchers. Receive weekly breakdowns of new compounds, safety data updates, and source verification reports.