AOD-9604
Synthetic peptide fragment derived from the C-terminal portion of human growth hormone, discussed in experimental and wellness contexts for potential effects on fat metabolism.
This page is for general educational and informational purposes only. It is not medical advice and does not replace professional medical judgment. Always consult a qualified clinician before starting, stopping, or changing any medication or protocol.
Overview
AOD-9604 is a synthetic peptide fragment corresponding to a portion of the C-terminal region of human growth hormone. It has been promoted in some experimental and commercial settings for potential roles in fat metabolism and weight-related endpoints.
Regulatory positions and claims about AOD-9604 vary widely by region and product type. Many uses described in marketing materials are more expansive than what is supported by formal, high-quality clinical evidence.
Mechanism of action
Proposed mechanisms for AOD-9604 are based largely on preclinical work and focus on potential effects on lipid metabolism and adipose tissue. High-level themes include:
- Acting on pathways involved in fat breakdown and energy expenditure
Attempting to separate certain metabolic effects of growth hormone from its broader endocrine footprint
How these mechanistic findings translate into meaningful, clinically relevant outcomes in humans is an area of ongoing debate and research.
Indications and use context
In many jurisdictions, AOD-9604 is not an approved medicine for weight management or metabolic disease. It may appear in experimental protocols or in wellness-oriented products marketed around fat loss.
Because regulatory status, product quality, and evidence strength vary, any consideration of AOD-9604 should be grounded in local regulations and a clear understanding of the difference between exploratory research and established obesity or metabolic treatments.
Anti-doping status
Status: Prohibited at all times (S0. Unapproved Substances)
AOD-9604 is classified as a prohibited substance by WADA under category S0 (Unapproved Substances).
Notable doping cases involving AOD-9604 include:
- Essendon Football Club (AFL): The most famous case involving AOD-9604. While players admitted to being injected with the substance, the final WADA-imposed bans were technically for Thymosin Beta-4 due to legal complexities. However, the saga highlighted AOD-9604's prohibited status.
Safety and side effects
Safety data for AOD-9604 are more limited than for long-established therapies, and many products are not part of tightly regulated drug frameworks.
Reported experiences include local injection-site reactions and nonspecific symptoms such as headache, fatigue, or GI upset. Robust, long-term safety data across diverse populations are relatively sparse.
As with other experimental peptides, careful attention to product sourcing, regulatory guidance, and individual risk factors is important. High-level summaries cannot substitute for rigorous safety evaluation.
Pharmacology and dosing considerations
AOD-9604 is a fragment of HGH (Tyr-hGH177-191) believed to influence lipid metabolism without the insulin-desensitizing effects of full HGH.
Route: Subcutaneous injection.
Protocol structure and dosage:- Dosage: 250 mcg to 500 mcg daily.
- Timing: Typically administered in the morning on a fasted stomach to maximize fat oxidation potential.
- Duration: Often used for 4–8 weeks or longer.
This information summarizes commonly discussed research practices and does not constitute medical advice.
Formulations and combinations
In catalogs, AOD-9604 usually appears as a lyophilized powder for reconstitution and may be positioned alongside other peptides associated with body composition themes.
Structural listings in this catalog are organizational and should not be read as endorsements of specific combinations, regimens, or use cases.
Research and evidence snapshot
Research on AOD-9604 has examined its effects on fat metabolism and related markers in preclinical models and limited human studies. Results have generated interest but also raised questions about effect size, study design, and reproducibility.
Because the evidence base is evolving and sometimes mixed, claims about AOD-9604 should be interpreted cautiously. High-level overviews are not a substitute for critical appraisal of primary data.
Frequently asked questions
Future FAQs may cover high-level questions such as how AOD-9604 relates conceptually to full-length growth hormone, what regulators have said about its marketing, and how clinicians think about experimental peptides in the context of established obesity treatments. Answers will remain educational and non-prescriptive.
Sport & Anti-Doping Warning
AOD-9604 has featured in high-profile anti-doping investigations, most notably the Essendon Football Club supplements saga in Australian rules football, where regulators clarified it was a non-approved substance prohibited at all times.
- >Essendon Football Club supplements saga (background)
- >Discussion of AOD-9604 and WADA's S0 (non-approved substances) category
For WADA-code athletes, AOD-9604 has been treated as prohibited under the S0 category, regardless of whether it is marketed as a 'research' or 'wellness' product.
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